There is no cure for PRP. Therefore, the goal of treatment is to relieve the symptoms.
According to the National Organization of Rare Diseases: “PRP tends to follow a natural waxing and waning course, with episodes in which there is periodic worsening (exacerbation) or cessation (remission) of symptoms.” Source: https://rarediseases.org/rare-diseases/pityriasis-rubra-pilaris/
From the PRP perspective, there are two major objectives in the treatment of pityriasis rubra pilaris:
✽ relieving symptoms as they present
✽ achieving long-term remission, if possible
The mantra heard within the PRP community is simple but deafening: “What works for one doesn’t work for all.”
TREATMENT OPTIONS
Oral retinoids are derivatives of vitamin A that slow the growth and shedding of skin cells.
✽ acitretin/Soriatane®
✽ isotretinoin/Accutane®
Immunosuppressants to slow down the body’s immune system. Often used when oral retinoids are ineffective.
✽ methotrexate (oral and injection)
✽ cyclosporine (oral and injection)
Biologicals with generally fewer side effects, targeted to reduce inflammation. These are injectable or intravenous (IV) medications that affect the immune system.
✽ adalimumab/Humira®
✽ etanercept/Enbrel®
✽ infliximab/Remicade®
✽ ustekinumab/Stelara®
✽ secukinumab/Cosentyx®
✽ apremilast/Otezla®
Ultraviolet light therapy — especially for Juvenile Onset PRP
Additional therapies
✽ topical creams and ointments
✽ Traditional Chinese Medicine
No meds at all is an option taken by PRP patients concerned with the negative impact of side effects.
OTHER CONSIDERATIONS
✽ Lab tests to monitor the effects of medications on the body and efficient management of drug side effects are important follow-up issues that will concern PRP patients and caregiver who is under a doctor’s care.
✽ Access to treatment options varies based on age, geography and cost.